Fatigue Modeling in Pediatric Muscle Populations
Understanding muscle contractile deficits in children with cerebral palsy
This graduate research project analyses the mechanical properties and fatigue response of single muscle fibers collected from children with cerebral palsy. The goal is to understand muscle contractile deficits and recovery using in vitro testing methods.
Project Overview
In collaboration with the Alberta Children’s Hospital and the McCaig Institute for Bone and Joint Health, we’re investigating how muscle fibers from children with cerebral palsy respond to repeated activation and fatigue. Using specialized equipment to measure active force production in isolated muscle fibers, we can quantify differences in contractile properties compared to typically developing children.
Key Research Questions
- How do the mechanical properties of muscle fibers differ in children with cerebral palsy?
- What are the underlying molecular mechanisms responsible for these differences?
- Can we develop targeted interventions based on these findings?
Current Progress
Our initial findings suggest significant differences in both the passive and active mechanical properties of muscle fibers, with potential implications for rehabilitation strategies and surgical interventions.
Related Research
Our work on this project has been presented at several conferences:
EMC Conference Presentation
Active properties of skinned muscle fibres from children with cerebral palsy. European Muscle Conference, Florence, Italy (2023)
View AbstractCASEM Conference Presentation
An investigation of active force in skeletal muscle fibres from children with cerebral palsy. Canadian Society of Sport and Exercise Medicine Conference (2023)